Silica-coated magnetic-nanoparticle-induced cytotoxicity is reduced in microglia by glutathione and citrate identified using integrated omics.

ABSTRACT:

Background

Nanoparticles have been utilized in brain research and therapeutics, including imaging, diagnosis, and drug delivery, owing to their versatile properties compared to bulk materials. However, exposure to nanoparticles leads to their accumulation in the brain, but drug development to counteract this nanotoxicity remains challenging. To date, concerns have risen about the potential toxicity to the brain associated with nanoparticles exposure via penetration of the brain blood barrier to address this issue.

Methods

Here the effect of silica-coated-magnetic nanoparticles containing the rhodamine B isothiocyanate dye [MNPs@SiO₂(RITC)] were assessed on microglia through toxicological investigation, including biological analysis and integration of transcriptomi

SUBMITTER: Shin TH 

PROVIDER: S-EPMC8614058 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature