The Role of Inflammatory Cytokines as Intermediates in the Pathway from Increased Adiposity to Disease.

ABSTRACT:

Objective

This study aimed to investigate the role of cytokines as intermediates in the pathway from increased adiposity to disease.

Methods

BMI and circulating levels of up to 41 cytokines were measured in individuals from three Finnish cohort studies (n = 8,293). Mendelian randomization (MR) was used to assess the impact of BMI on circulating cytokines and the impact of BMI-driven cytokines on risk of obesity-related diseases.

Results

Observationally, BMI was associated with 19 cytokines. For every SD increase in BMI, causal effect estimates were strongest for hepatocyte growth factor, monocyte chemotactic protein-1 (MCP-1), and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and were as ratios of geometric means 1.13 (95% CI: 1.08-1.19), 1.08 (95% C

SUBMITTER: Kalaoja M 

PROVIDER: S-EPMC8614117 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature