Predicting opioid-induced oversedation in hospitalised patients: a multicentre observational study.

ABSTRACT:

Objectives

Opioid-induced respiratory depression (OIRD) and oversedation are rare but potentially devastating adverse events in hospitalised patients. We investigated which features predict an individual patient's risk of OIRD or oversedation; and developed a risk stratification tool that can be used to aid point-of-care clinical decision-making.

Design

Retrospective observational study.

Setting

Twelve acute care hospitals in a large not-for-profit integrated delivery system.

Participants

All inpatients ≥18 years admitted between 1 July 2016 and 30 June 2018 who received an opioid during their stay (163 190 unique hospitalisations).

Main outcome measures

The primary outcome was occurrence of sedation or respiratory depression severe enough that emergent

SUBMITTER: Garrett J 

PROVIDER: S-EPMC8614135 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature