Hemoglobin glycation index, calculated from a single fasting glucose value, as a prediction tool for severe hypoglycemia and major adverse cardiovascular events in DEVOTE.

ABSTRACT:

Introduction

Hemoglobin glycation index (HGI) is the difference between observed and predicted glycated hemoglobin A1c (HbA_1c), derived from mean or fasting plasma glucose (FPG). In this secondary, exploratory analysis of data from DEVOTE, we examined: whether insulin initiation/titration affected the HGI; the relationship between baseline HGI tertile and cardiovascular and hypoglycemia risk; and the relative strengths of HGI and HbA_1c in predicting these risks.

Research design and methods

In DEVOTE, a randomized, double-blind, cardiovascular outcomes trial, people with type 2 diabetes received once per day insulin degludec or insulin glargine 100 units/mL. The primary outcome was time to first occurrence of a major adverse cardiovascular event (MACE),

SUBMITTER: Klein KR 

PROVIDER: S-EPMC8614152 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature