Role of PARP in TNBC: Mechanism of Inhibition, Clinical Applications, and Resistance.

ABSTRACT: Triple-negative breast cancer is a combative cancer type with a highly inflated histological grade that leads to poor theragnostic value. Gene, protein, and receptor-specific targets have shown effective clinical outcomes in patients with TNBC. Cells are frequently exposed to DNA-damaging agents. DNA damage is repaired by multiple pathways; accumulations of mutations occur due to damage to one or more pathways and lead to alterations in normal cellular mechanisms, which lead to development of tumors. Advances in target-specific cancer therapies have shown significant momentum; most treatment options cause off-target toxicity and side effects on healthy tissues. PARP (poly(ADP-ribose) polymerase) is a major protein and is involved in DNA repair pathways, base excision repair (BER) mechanism

SUBMITTER: Singh DD 

PROVIDER: S-EPMC8614648 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature