Inflammatory Response Modulation by Vitamin C in an MPTP Mouse Model of Parkinson's Disease.

ABSTRACT: Vitamin C (Vit C) is anutrient present in many foods, particularly citrus fruits, green vegetables, tomatoes, and potatoes. Vit C is studied for its applications in the prevention and management of different pathologies, including neurodegenerative diseases. Neuroinflammation is a defense mechanism activated by a stimulus or an insult that is aimed at the preservation of the brain by promoting tissue repair and removing cellular debris; however, persistent inflammatory responses are detrimental and may lead to the pathogenesis and progression of neurodegenerative diseases like Parkinson's disease (PD) and Alzheimer's disease. PD is one of the most common chronic progressive neurodegenerative disorders, and oxidative stress is one of the most important factors involved in its pathogenesis a

SUBMITTER: De Nuccio F 

PROVIDER: S-EPMC8614932 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature