Cell-Based Neuroprotection of Retinal Ganglion Cells in Animal Models of Optic Neuropathies.

ABSTRACT: Retinal ganglion cells (RGCs) comprise a heterogenous group of projection neurons that transmit visual information from the retina to the brain. Progressive degeneration of these cells, as it occurs in inflammatory, ischemic, traumatic or glaucomatous optic neuropathies, results in visual deterioration and is among the leading causes of irreversible blindness. Treatment options for these diseases are limited. Neuroprotective approaches aim to slow down and eventually halt the loss of ganglion cells in these disorders. In this review, we have summarized preclinical studies that have evaluated the efficacy of cell-based neuroprotective treatment strategies to rescue retinal ganglion cells from cell death. Intraocular transplantations of diverse genetically nonmodified cell types or cells eng

SUBMITTER: Hu Y 

PROVIDER: S-EPMC8615038 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature