Systematic Review of Antimicrobial Combination Options for Pandrug-Resistant Acinetobacter baumannii.

ABSTRACT: Antimicrobial combinations are at the moment the only potential treatment option for pandrug-resistant A. baumannii. A systematic review was conducted in PubMed and Scopus for studies reporting the activity of antimicrobial combinations against A. baumannii resistant to all components of the combination. The clinical relevance of synergistic combinations was assessed based on concentrations achieving synergy and PK/PD models. Eighty-four studies were retrieved including 818 eligible isolates. A variety of combinations (n = 141 double, n = 9 triple) were tested, with a variety of methods. Polymyxin-based combinations were the most studied, either as double or triple combinations with cell-wall acting agents (including sulbactam, carbapenems, glycopeptides), rifamycins and fosfomycin. Non-po

SUBMITTER: Karakonstantis S 

PROVIDER: S-EPMC8615225 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature