Correlation between Previous Antibiotic Exposure and COVID-19 Severity. A Population-Based Cohort Study.

ABSTRACT: We examined the correlation between previous antibiotic exposure and COVID-19 severity using a population-based observational matched cohort study with patient level data obtained for more than 5.8 million people registered in SIDIAP in Catalonia, Spain. We included all patients newly diagnosed with COVID-19 from March to June 2020 and identified all their antibiotic prescriptions in the previous two years. We used a composite severity endpoint, including pneumonia, hospital admission and death due to COVID-19. We examined the influence of high antibiotic exposure (>4 regimens), exposure to highest priority critically important antimicrobials (HPCIA) and recent exposure. Potential confounders were adjusted by logistic regression. A total of 280,679 patients were diagnosed with COVID-19, 14

SUBMITTER: Llor C 

PROVIDER: S-EPMC8615228 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature