Anti-Inflammatory Effects of the Novel Barbiturate Derivative MHY2699 in an MPTP-Induced Mouse Model of Parkinson's Disease.
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SUBMITTER: Lee S
PROVIDER: S-EPMC8615243 | biostudies-literature | 2021 Nov
REPOSITORIES: biostudies-literature
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Anti-Inflammatory Effects of the Novel Barbiturate Derivative MHY2699 in an MPTP-Induced Mouse Model of Parkinson's Disease.
Lee Seulah S Suh Yeon Ji YJ Lee Yujeong Y Yang Seonguk S Hong Dong Geun DG Thirumalai Dinakaran D Chang Seung-Cheol SC Chung Ki Wung KW Jung Young-Suk YS Moon Hyung Ryong HR Chung Hae Young HY Lee Jaewon J
Antioxidants (Basel, Switzerland) 20211122 11
Parkinson's disease (PD) is one of the most common neurodegenerative disorders, and is caused by the death of dopamine neurons and neuroinflammation in the striatum and substantia nigra. Furthermore, the inflammatory response in PD is closely related to glial cell activation. This study examined the neuroprotective effects of the barbiturate derivative, MHY2699 [5-(4-hydroxy 3,5-dimethoxybenzyl)-2 thioxodihydropyrimidine-4,6(1H,5H)-dione] in a mouse model of PD. MHY2699 ameliorated MPP⁺-induced ...[more]
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