Impact of the Innate Inflammatory Response on ICU Admission and Death in Hospitalized Patients with COVID-19.

ABSTRACT: To describe the capacity of a broad spectrum of cytokines and growth factors to predict ICU admission and/or death in patients with severe COVID-19. An observational, analytical, retrospective cohort study with longitudinal follow-up. Hospital Universitario Príncipe de Asturias (HUPA). 287 patients diagnosed with COVID-19 admitted to our hospital from 24 March to 8 May 2020, followed until 31 August 2020. Profiles of immune response (IR) mediators were determined using the Luminex Multiplex technique in hospitalized patients within six days of admission by examining serum levels of 62 soluble molecules classified into the three groups: adaptive IR-related cytokines (n = 19), innate inflammatory IR-related cytokines (n = 27), and growth factors (n = 16). A statistically robust link with ICU

SUBMITTER: Monserrat J 

PROVIDER: S-EPMC8615389 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature