An Additively Manufactured Sample Holder to Measure the Controlled Release of Vancomycin from Collagen Laminates.

ABSTRACT: The controlled release of antibiotics prevents the spread of pathogens and thereby improves healing processes in regenerative medicine. However, high concentrations may interfere with healing processes. It is therefore advantageous to use biodegradable materials for a controlled release. In particular, multilayer materials enable differential release at different surfaces. For this purpose, collagen sheets of different properties can be bonded by photochemical crosslinking. Here, we present the development and application of an easily accessible, additively manufactured sample holder to study the controlled release of vancomycin from modularly assembled collagen laminates in two directions. As proof-of-concept, we show that laminates of collagen sheets covalently linked by rose bengal and

SUBMITTER: Kilb MF 

PROVIDER: S-EPMC8615449 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature