Cytotoxicity and Mitochondrial Effects of Phenolic and Quinone-Based Mitochondria-Targeted and Untargeted Antioxidants on Human Neuronal and Hepatic Cell Lines: A Comparative Analysis.

ABSTRACT: Mitochondriotropic antioxidants (MC₃, MC_6.2, MC₄ and MC_7.2) based on dietary antioxidants and analogs (caffeic, hydrocaffeic, trihydroxyphenylpropanoic and trihydroxycinnamic acids) were developed. In this study, we evaluate and compare the cytotoxicity profile of novel mitochondria-targeted molecules (generally known as MitoCINs) on human HepG2 and differentiated SH-SY5Y cells with the quinone-based mitochondria-targeted antioxidants MitoQ and SkQ₁ and with two non-targeted antioxidants, resveratrol and coenzyme Q₁₀ (CoQ₁₀). We further evaluate their effects on mitochondrial membrane potential, cellular oxygen consumption and extracellular acidification rates. Overall, MitoCINs derivatives reduced cell viability

SUBMITTER: Fernandes C 

PROVIDER: S-EPMC8615458 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature