Relationships between Freezing of Gait Severity and Cognitive Deficits in Parkinson's Disease.

ABSTRACT: Freezing of gait (FOG) is one of the most debilitating motor symptoms experienced by patients with Parkinson's disease (PD), as it can lead to falls and a reduced quality of life. Evidence supports an association between FOG severity and cognitive functioning; however, results remain debatable. PD patients with (PDFOG+, n = 41) and without FOG (PDFOG-, n = 39) and control healthy subjects (n = 41) participated in this study. The NIH toolbox cognition battery, the Montreal Cognitive Assessment (MoCA), and the interval timing task were used to test cognitive domains. Measurements were compared between groups using multivariable models and adjusting for covariates. Correlation analyses, linear regression, and mediation models were applied to examine relationships among disease duration and se

SUBMITTER: Scholl JL 

PROVIDER: S-EPMC8615553 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature