Ferroptosis as a Major Factor and Therapeutic Target for Neuroinflammation in Parkinson's Disease.

ABSTRACT: Mounting evidence suggests that ferroptosis is not just a consequence but also a fundamental contributor to the development and progression of Parkinson's disease (PD). Ferroptosis is characterized as iron-dependent regulated cell death caused by excessive lipid peroxidation, leading to plasma membrane rupture, release of damage-associated molecular patterns, and neuroinflammation. Due to the crucial role of intracellular iron in mediating the production of reactive oxygen species and the formation of lipid peroxides, ferroptosis is intimately controlled by regulators involved in many aspects of iron metabolism, including iron uptake, storage and export, and by pathways constituting the antioxidant systems. Translational and transcriptional regulation of iron homeostasis and redox status p

SUBMITTER: Ko CJ 

PROVIDER: S-EPMC8615560 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature