Striatal Dopamine Transporter Availability Is Not Associated with Food Craving in Lean and Obese Humans; a Molecular Imaging Study.
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ABSTRACT:
SUBMITTER: van Son J
PROVIDER: S-EPMC8615750 | biostudies-literature | 2021 Oct
REPOSITORIES: biostudies-literature
Publications
Striatal Dopamine Transporter Availability Is Not Associated with Food Craving in Lean and Obese Humans; a Molecular Imaging Study.
van Son Jamie J van Galen Katy A KA Bruijn Anne Marijn AM Koopman Karin E KE Versteeg Ruth I RI la Fleur Susanne E SE Serlie Mireille J MJ Booij Jan J
Brain sciences 20211028 11
Brain dopamine signaling is essential for the motivation to eat, and obesity is associated with altered dopaminergic signaling and increased food craving. We used molecular neuroimaging to explore whether striatal dopamine transporter (DAT) availability is associated with craving as measured with the General Food Craving Questionnaire-Trait (G-FCQ-T). We here show that humans with obesity (<i>n</i> = 34) experienced significantly more craving for food compared with lean subjects (<i>n</i> = 32), ...[more]
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