Effects of Exercise Training on Neurotrophic Factors and Subsequent Neuroprotection in Persons with Multiple Sclerosis-A Systematic Review and Meta-Analysis.

ABSTRACT:

Background

Evidence indicates that exercise holds the potential to counteract neurodegeneration experienced by persons with multiple sclerosis (pwMS), which is in part believed to be mediated through increases in neurotrophic factors. There is a need to summarize the existing evidence on exercise-induced effects on neurotrophic factors alongside neuroprotection in pwMS.

Aim

To (1) systematically review the evidence on acute (one session) and/or chronic (several sessions) exercise-induced changes in neurotrophic factors in pwMS and (2) investigate the potential translational link between exercise-induced changes in neurotrophic factors and neuroprotection.

Methods

Five databases (Medline, Scopus, Web of Science, Embase, Sport Discus) were searched for randomized contro

SUBMITTER: Diechmann MD 

PROVIDER: S-EPMC8615767 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature