Involvement of retinoblastoma protein and HBP1 in histone H1(0) gene expression.

ABSTRACT: The histone H1(0)-encoding gene is expressed in vertebrates in differentiating cells during the arrest of proliferation. In the H1(0) promoter, a specific regulatory element, which we named the H4 box, exhibits features which implicate a role in mediating H1(0) gene expression in response to both differentiation and cell cycle control signals. For instance, within the linker histone gene family, the H4 box is found only in the promoters of differentiation-associated subtypes, suggesting that it is specifically involved in differentiation-dependent expression of these genes. In addition, an element nearly identical to the H4 box is conserved in the promoters of histone H4-encoding genes and is known to be involved in their cell cycle-dependent expression. The transcription factors interacti

SUBMITTER: Lemercier C 

PROVIDER: S-EPMC86159 | biostudies-literature | 2000 Sep

REPOSITORIES: biostudies-literature