Age-Related Intrinsic Functional Connectivity Changes of Locus Coeruleus from Childhood to Older Adults.

ABSTRACT: The locus coeruleus is critical for selective information processing by modulating the brain's connectivity configuration. Increasingly, studies have suggested that LC controls sensory inputs at the sensory gating stage. Furthermore, accumulating evidence has shown that young children and older adults are more prone to distraction and filter out irrelevant information less efficiently, possibly due to the unoptimized LC connectivity. However, the LC connectivity pattern across the life span is not fully examined yet, hampering our ability to understand the relationship between LC development and the distractibility. In this study, we examined the intrinsic network connectivity of the LC using a public fMRI dataset with wide-range age samples. Based on LC-seed functional connectivity maps,

SUBMITTER: Song I 

PROVIDER: S-EPMC8615904 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature