Possible Role of Leptin in Atopic Dermatitis: A Literature Review.

ABSTRACT: Atopic dermatitis (AD) is the most frequent chronic inflammatory skin disease, and its incidence has been rapidly increasing in developed countries in the last years. AD presents a high degree of heterogeneity due to biases and confounding factors such as age range, sex, or ethnicity. For those reasons, the search for new biomarkers is crucial. At the same time, obesity, which is a global health problem, has also increased over the years. It has been associated with many pathophysiological states, including skin diseases such as AD, mostly in childhood. Obesity promotes a low grade inflammation driven by many different cytokines and adipokines, including leptin, which has a key role in many other diseases due to its pleiotropic effects. Leptin also has a role in both skin and allergic dise

SUBMITTER: Jimenez-Cortegana C 

PROVIDER: S-EPMC8616015 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature