Risk Stratification of Endometrial Cancer Patients: FIGO Stage, Biomarkers and Molecular Classification.

ABSTRACT: Endometrial cancer (EC) is the most common gynaecologic malignancy in developed countries. The main challenge in EC management is to correctly estimate the risk of metastases at diagnosis and the risk to develop recurrences in the future. Risk stratification determines the need for surgical staging and adjuvant treatment. Detection of occult, microscopic metastases upstages patients, provides important prognostic information and guides adjuvant treatment. The molecular classification subdivides EC into four prognostic subgroups: POLE ultramutated; mismatch repair deficient (MMRd); nonspecific molecular profile (NSMP); and TP53 mutated (p53abn). How surgical staging should be adjusted based on preoperative molecular profiling is currently unknown. Moreover, little is known whether and how o

SUBMITTER: Kasius JC 

PROVIDER: S-EPMC8616052 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature