Molecular Characterization of Membrane Steroid Receptors in Hormone-Sensitive Cancers.

ABSTRACT: Cancer is one of the most common causes of death worldwide, and its development is a result of the complex interaction of genetic factors, environmental cues, and aging. Hormone-sensitive cancers depend on the action of one or more hormones for their development and progression. Sex steroids and corticosteroids can regulate different physiological functions, including metabolism, growth, and proliferation, through their interaction with specific nuclear receptors, that can transcriptionally regulate target genes via their genomic actions. Therefore, interference with hormones' activities, e.g., deregulation of their production and downstream pathways or the exposition to exogenous hormone-active substances such as endocrine-disrupting chemicals (EDCs), can affect the regulation of their co

SUBMITTER: Masi M 

PROVIDER: S-EPMC8616056 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature