The Potential of Induced Pluripotent Stem Cells to Advance the Treatment of Pancreatic Ductal Adenocarcinoma.
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ABSTRACT:
SUBMITTER: Krog RT
PROVIDER: S-EPMC8616212 | biostudies-literature | 2021 Nov
REPOSITORIES: biostudies-literature
Publications
The Potential of Induced Pluripotent Stem Cells to Advance the Treatment of Pancreatic Ductal Adenocarcinoma.
Krog Ricki T RT de Miranda Noel F C C NFCC Vahrmeijer Alexander L AL Kooreman Nigel G NG
Cancers 20211118 22
Advances in the treatment of pancreatic ductal adenocarcinoma (PDAC) using neoadjuvant chemoradiotherapy, chemotherapy, and immunotherapy have had minimal impact on the overall survival of patients. A general lack of immunogenic features and a complex tumor microenvironment (TME) are likely culprits for therapy refractoriness in PDAC. Induced pluripotent stem cells (iPSCs) should be explored as a means to advance the treatment options for PDAC, by providing representative in vitro models of panc ...[more]
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