Polypeptide-GalNAc-Transferase-13 Shows Prognostic Impact in Breast Cancer.

ABSTRACT: Breast cancer is a public health concern and is currently the fifth cause of mortality worldwide. Identification of different biological subtypes is essential for clinical management; therefore, the role of pathologists is essential and useful tools for immunohistochemistry diagnosis are needed. Polypeptide-GalNAc-transferases are emerging novel biomarkers related to cancer behavior and GalNAc-T13, correlated with aggressiveness in some tumors, is an interesting candidate. Few monoclonal antibodies reacting with native proteins, and not affected by fixation and paraffin embedding, have been reported. The aim of this work was to develop a useful monoclonal antibody anti-GalNAc-T13 and to assess its potential significance in breast cancer diagnosis. We evaluated 6 human breast cancer cell li

SUBMITTER: Fernandez E 

PROVIDER: S-EPMC8616257 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature