Changes in Cell Morphology and Actin Organization in Embryonic Stem Cells Cultured under Different Conditions.

ABSTRACT: The cellular cytoskeleton provides the cell with a mechanical rigidity that allows mechanical interaction between cells and the extracellular environment. The actin structure plays a key role in mechanical events such as motility or the establishment of cell polarity. From the earliest stages of development, as represented by the ex vivo expansion of naïve embryonic stem cells (ESCs), the critical mechanical role of the actin structure is becoming recognized as a vital cue for correct segregation and lineage control of cells and as a regulatory structure that controls several transcription factors. Naïve ESCs have a characteristic morphology, and the ultrastructure that underlies this condition remains to be further investigated. Here, we investigate the 3D actin cytoskeleton of naïve mous

SUBMITTER: Barooji YF 

PROVIDER: S-EPMC8616278 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature