Cognitive Impairment in Long-Term Survivors of Testicular Cancer More Than 20 Years after Treatment.

ABSTRACT:

Background

Impaired cognition can be a late effect after treatment in long-term testicular cancer (TC) survivors, negatively affecting their daily life. However, little data is available beyond 20 years post-treatment. We assessed cognitive impairment in very long-term TC survivors after CT or RT and compared the results with stage I TC survivors and controls.

Methods

In this cross-sectional multicenter cohort study, we enrolled TC survivors (treated with orchiectomy followed by CT or RT or orchiectomy only)-with a follow-up duration ≥ 20 years-and age-matched healthy controls. Cognitive testing included the Auditory Verbal Learning Test, Letter Fluency Test, Category Fluency Test, and Trail Making Test. We used fasting blood samples to assess the presence of hypogonadism an

SUBMITTER: Stelwagen J 

PROVIDER: S-EPMC8616311 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature