Inhibitors of the Plasmodium falciparum Hsp90 towards Selective Antimalarial Drug Design: The Past, Present and Future.
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ABSTRACT:
SUBMITTER: Stofberg ML
PROVIDER: S-EPMC8616389 | biostudies-literature | 2021 Oct
REPOSITORIES: biostudies-literature
Publications
Inhibitors of the <i>Plasmodium falciparum</i> Hsp90 towards Selective Antimalarial Drug Design: The Past, Present and Future.
Stofberg Melissa Louise ML Caillet Celine C de Villiers Marianne M Zininga Tawanda T
Cells 20211022 11
Malaria is still one of the major killer parasitic diseases in tropical settings, posing a public health threat. The development of antimalarial drug resistance is reversing the gains made in attempts to control the disease. The parasite leads a complex life cycle that has adapted to outwit almost all known antimalarial drugs to date, including the first line of treatment, artesunate. There is a high unmet need to develop new strategies and identify novel therapeutics to reverse antimalarial dru ...[more]
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