Bile Acid Receptors and the Gut-Liver Axis in Nonalcoholic Fatty Liver Disease.

ABSTRACT: The prevalence of nonalcoholic fatty liver disease (NAFLD) has been significantly increased due to the global epidemic of obesity. The disease progression from simple steatosis (NAFL) to nonalcoholic steatohepatitis (NASH) is closely linked to inflammation, insulin resistance, and dysbiosis. Although extensive efforts have been aimed at elucidating the pathological mechanisms of NAFLD disease progression, current understanding remains incomplete, and no effective therapy is available. Bile acids (BAs) are not only important physiological detergents for the absorption of lipid-soluble nutrients in the intestine but also metabolic regulators. During the last two decades, BAs have been identified as important signaling molecules involved in lipid, glucose, and energy metabolism. Dysregulation

SUBMITTER: Xue R 

PROVIDER: S-EPMC8616422 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature