Prompt Graft Cooling Enhances Cardioprotection during Heart Transplantation Procedures through the Regulation of Mitophagy.

ABSTRACT: A complete and prompt cardiac arrest using a cold cardioplegic solution is routinely used in heart transplantation to protect the graft function. However, warm ischemic time is still inevitable during the procedure to isolate donor hearts in the clinical setting. Our knowledge of the mechanism changes prevented by cold storage, and how warm ischemia damages donor hearts, is extremely poor. The potential consequences of this inevitable warm ischemic time to grafts, and the underlying potential protective mechanism of prompt graft cooling, have been studied in order to explore an advanced graft protection strategy. To this end, a surgical procedure, including 10-15 min warm ischemic time during procurement, was performed in mouse models to mimic the clinical situation (Group I), and compared

SUBMITTER: Wu Z 

PROVIDER: S-EPMC8616468 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature