Metabolic Plasticity in Melanoma Progression and Response to Oncogene Targeted Therapies.

ABSTRACT: Resistance to therapy continues to be a barrier to curative treatments in melanoma. Recent insights from the clinic and experimental settings have highlighted a range of non-genetic adaptive mechanisms that contribute to therapy resistance and disease relapse, including transcriptional, post-transcriptional and metabolic reprogramming. A growing body of evidence highlights the inherent plasticity of melanoma metabolism, evidenced by reversible metabolome alterations and flexibility in fuel usage that occur during metastasis and response to anti-cancer therapies. Here, we discuss how the inherent metabolic plasticity of melanoma cells facilitates both disease progression and acquisition of anti-cancer therapy resistance. In particular, we discuss in detail the different metabolic changes th

SUBMITTER: Alkaraki A 

PROVIDER: S-EPMC8616485 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature