Ontology highlight
ABSTRACT:
SUBMITTER: Zhou S
PROVIDER: S-EPMC8616580 | biostudies-literature | 2021 Nov
REPOSITORIES: biostudies-literature
Zhou Shan S Wang Weiwei W Zhou Xiaoting X Zhang Yuying Y Lai Yuezheng Y Tang Yanting Y Xu Jinxu J Li Dongmei D Lin Jianping J Yang Xiaolin X Ran Ting T Chen Hongming H Guddat Luke W LW Wang Quan Q Gao Yan Y Rao Zihe Z Gong Hongri H
eLife 20211125
Pathogenic mycobacteria pose a sustained threat to global human health. Recently, cytochrome <i>bcc</i> complexes have gained interest as targets for antibiotic drug development. However, there is currently no structural information for the cytochrome <i>bcc</i> complex from these pathogenic mycobacteria. Here, we report the structures of <i>Mycobacterium tuberculosis</i> cytochrome <i>bcc</i> alone (2.68 Å resolution) and in complex with clinical drug candidates Q203 (2.67 Å resolution) and TB4 ...[more]