HOPX⁺ injury-resistant intestinal stem cells drive epithelial recovery after severe intestinal ischemia.

ABSTRACT: Intestinal ischemia is a life-threatening emergency with mortality rates of 50%-80% due to epithelial cell death and resultant barrier loss. Loss of the epithelial barrier occurs in conditions including intestinal volvulus and neonatal necrotizing enterocolitis. Survival depends on effective epithelial repair; crypt-based intestinal epithelial stem cells (ISCs) are the source of epithelial renewal in homeostasis and after injury. Two ISC populations have been described: 1) active ISC [aISC; highly proliferative; leucine-rich-repeat-containing G protein-coupled receptor 5 (LGR5⁺)-positive or sex-determining region Y-box 9 -antigen Ki67-positive (SOX9⁺Ki67⁺)] and 2) reserve ISC [rISC; less proliferative; homeodomain-only protein X positive (HOPX

SUBMITTER: Stewart AS 

PROVIDER: S-EPMC8616590 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature