Comparative impact of dietary carbohydrates on the liver transcriptome in two strains of mice.

ABSTRACT: Excessive long-term consumption of dietary carbohydrates, including glucose, sucrose, or fructose, has been shown to have significant impact on genome-wide gene expression, which likely results from changes in metabolic substrate flux. However, there has been no comprehensive study on the acute effects of individual sugars on the genome-wide gene expression that may reveal the genetic changes altering signaling pathways, subsequent metabolic processes, and ultimately physiological/pathological responses. Considering that gene expressions in response to acute carbohydrate ingestion might be different in nutrient sensitive and insensitive mammals, we conducted comparative studies of genome-wide gene expression by deep mRNA sequencing of the liver in nutrient sensitive C57BL/6J and nutrient i

SUBMITTER: Chi Y 

PROVIDER: S-EPMC8616594 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature