Chronic Porphyromonas gingivalis lipopolysaccharide induces adverse myocardial infarction wound healing through activation of CD8⁺ T cells.

ABSTRACT: Oral and gum health have long been associated with incidence and outcomes of cardiovascular disease. Periodontal disease increases myocardial infarction (MI) mortality by sevenfold through mechanisms that are not fully understood. The goal of this study was to evaluate whether lipopolysaccharide (LPS) from a periodontal pathogen accelerates inflammation after MI through memory T-cell activation. We compared four groups [no MI, chronic LPS, day 1 after MI, and day 1 after MI with chronic LPS (LPS + MI); n = 68 mice] using the mouse heart attack research tool 1.0 database and tissue bank coupled with new analyses and experiments. LPS + MI increased total CD8⁺ T cells in the left ventricle versus the other groups (P < 0.05 vs. all). Memory CD8⁺

SUBMITTER: Zaidi Y 

PROVIDER: S-EPMC8616607 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature