Contribution of tetrodotoxin-sensitive, voltage-gated sodium channels (Na_V1) to action potential discharge from mouse esophageal tension mechanoreceptors.

ABSTRACT: Action potentials depend on voltage-gated sodium channels (Na_V1s), which have nine α subtypes. Na_V1 inhibition is a target for pathologies involving excitable cells such as pain. However, because Na_V1 subtypes are widely expressed, inhibitors may inhibit regulatory sensory systems. Here, we investigated specific Na_V1s and their inhibition in mouse esophageal mechanoreceptors-non-nociceptive vagal sensory afferents that are stimulated by low threshold mechanical distension, which regulate esophageal motility. Using single fiber electrophysiology, we found mechanoreceptor responses to esophageal distension were abolished by tetrodotoxin. Single-cell RT-PCR revealed that esophageal-labeled TRPV1-negative vagal neurons expressed multiple tetrodotoxin

SUBMITTER: Hadley S 

PROVIDER: S-EPMC8616622 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature