Metabolite profiles and the risk of metabolic syndrome in early childhood: a case-control study.

ABSTRACT:

Background

Defining the metabolic syndrome (MetS) in children remains challenging. Furthermore, a dichotomous MetS diagnosis can limit the power to study associations. We sought to characterize the serum metabolite signature of the MetS in early childhood using high-throughput metabolomic technologies that allow comprehensive profiling of metabolic status from a biospecimen.

Methods

In the Family Atherosclerosis Monitoring In earLY life (FAMILY) prospective birth cohort study, we selected 228 cases of MetS and 228 matched controls among children age 5 years. In addition, a continuous MetS risk score was calculated for all 456 participants. Comprehensive metabolite profiling was performed on fasting serum samples using multisegment injection-capillary electrophoresis-mass spe

SUBMITTER: Azab SM 

PROVIDER: S-EPMC8616718 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature