Free-breathing multitasking multi-echo MRI for whole-liver water-specific T₁ , proton density fat fraction, and R2∗ quantification.

ABSTRACT:

Purpose

To develop a 3D multitasking multi-echo (MT-ME) technique for the comprehensive characterization of liver tissues with 5-min free-breathing acquisition; whole-liver coverage; a spatial resolution of 1.5 × 1.5 × 6 mm³ ; and simultaneous quantification of T₁ , water-specific T₁ (T_1w ), proton density fat fraction (PDFF), and R2∗ .

Methods

Six-echo bipolar spoiled gradient echo readouts following inversion recovery preparation was performed to generate T₁ , water/fat, and R2∗ contrast. MR multitasking was used to reconstruct the MT-ME images with 3 spatial dimensions: 1 T₁ recovery dimension, 1 multi-echo dimension, and 1 respiratory dimension. A basis function-based approach was developed for T_1w

SUBMITTER: Wang N 

PROVIDER: S-EPMC8616772 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature