Topology evaluation of models for difficult targets in the 14th round of the critical assessment of protein structure prediction (CASP14).

ABSTRACT: This report describes the tertiary structure prediction assessment of difficult modeling targets in the 14th round of the Critical Assessment of Structure Prediction (CASP14). We implemented an official ranking scheme that used the same scores as the previous CASP topology-based assessment, but combined these scores with one that emphasized physically realistic models. The top performing AlphaFold2 group outperformed the rest of the prediction community on all but two of the difficult targets considered in this assessment. They provided high quality models for most of the targets (86% over GDT_TS 70), including larger targets above 150 residues, and they correctly predicted the topology of almost all the rest. AlphaFold2 performance was followed by two manual Baker methods, a Feig method t

SUBMITTER: Kinch LN 

PROVIDER: S-EPMC8616777 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature