Phthalates and attributable mortality: A population-based longitudinal cohort study and cost analysis.

ABSTRACT:

Context

Accelerating evidence of endocrine-related morbidity has raised alarm about the ubiquitous use of phthalates in the human environment, but studies have not directly evaluated mortality in relation to these exposures.

Objectives

To evaluate associations of phthalate exposure with mortality, and quantify attributable mortality and lost economic productivity in 2013-4 among 55-64 year olds.

Design

This nationally representative cohort study included 5303 adults aged 20 years or older who participated in the US National Health and Nutrition Examination Survey 2001-2010 and provided urine samples for phthalate metabolite measurements. Participants were linked to mortality data from survey date through December 31, 2015. Data analyses were conducted in July 2020.

SUBMITTER: Trasande L 

PROVIDER: S-EPMC8616787 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature