Computational models in the service of X-ray and cryo-electron microscopy structure determination.

ABSTRACT: Critical assessment of structure prediction (CASP) conducts community experiments to determine the state of the art in computing protein structure from amino acid sequence. The process relies on the experimental community providing information about not yet public or about to be solved structures, for use as targets. For some targets, the experimental structure is not solved in time for use in CASP. Calculated structure accuracy improved dramatically in this round, implying that models should now be much more useful for resolving many sorts of experimental difficulties. To test this, selected models for seven unsolved targets were provided to the experimental groups. These models were from the AlphaFold2 group, who overall submitted the most accurate predictions in CASP14. Four targets wer

SUBMITTER: Kryshtafovych A 

PROVIDER: S-EPMC8616789 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature