In vivo spectral editing of phosphorylethanolamine.

ABSTRACT:

Purpose

To demonstrate J-difference editing of phosphorylethanolamine (PE) with chemical shifts at 3.22 (PE_3.22 ) and 3.98 (PE_3.98 ) ppm, and compare the merits of two editing strategies.

Methods

Density-matrix simulations of MEGA-PRESS (Mescher-Garwood PRESS) for PE were performed at TEs ranging from 80 to 200 ms in steps of 2 ms, applying 20-ms editing pulses (ON/OFF) at (1) 3.98/7.5 ppm to detect PE_3.22 and (2) 3.22/7.5 ppm to detect PE_3.98 . Phantom experiments were performed using a PE phantom to validate simulation results. Ten subjects were scanned using a Philips 3T MRI scanner at TEs of 90 ms and 110 ms to edit PE_3.22 and PE_3.98 . Osprey was used for data processing, modeling, and quantification.

R

SUBMITTER: Hui SCN 

PROVIDER: S-EPMC8616810 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature