Physiologically Based Pharmacokinetic Modeling of Meropenem in Preterm and Term Infants.

ABSTRACT:

Background

Meropenem is a broad-spectrum carbapenem antibiotic approved by the US Food and Drug Administration for use in pediatric patients, including treating complicated intra-abdominal infections in infants < 3 months of age. The impact of maturation in glomerular filtration rate and tubular secretion by renal transporters on meropenem pharmacokinetics, and the effect on meropenem dosing, remains unknown. We applied physiologically based pharmacokinetic (PBPK) modeling to characterize the disposition of meropenem in preterm and term infants.

Methods

An adult meropenem PBPK model was developed in PK-Sim^® (Version 8) and scaled to infants accounting for renal transporter ontogeny and glomerular filtration rate maturation. The PBPK model was evaluated using 645 p

SUBMITTER: Ganguly S 

PROVIDER: S-EPMC8616812 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature