Assessment of domain interactions in the fourteenth round of the Critical Assessment of Structure Prediction (CASP14).

ABSTRACT: The high accuracy of some CASP14 models at the domain level prompted a more detailed evaluation of structure predictions on whole targets. For the first time in critical assessment of structure prediction (CASP), we evaluated accuracy of difficult domain assembly in models submitted for multidomain targets where the community predicted individual evaluation units (EUs) with greater accuracy than full-length targets. Ten proteins with domain interactions that did not show evidence of conformational change and were not involved in significant oligomeric contacts were chosen as targets for the domain interaction assessment. Groups were ranked using complementary interaction scores (F1, QS score, and Jaccard coefficient), and their predictions were evaluated for their ability to correctly mode

SUBMITTER: Schaeffer RD 

PROVIDER: S-EPMC8616818 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature