Dual-phase imaging of cardiac metabolism using hyperpolarized pyruvate.

ABSTRACT:

Purpose

Previous cardiac imaging studies using hyperpolarized (HP) [1-¹³ C]pyruvate were acquired at end-diastole (ED). Little is known about the interaction between cardiac cycle and metabolite content in the myocardium. In this study, we compared images of HP pyruvate and products at end-systole (ES) and ED.

Methods

A dual-phase ¹³ C MRI sequence was implemented to acquire two sequential HP images within a single cardiac cycle at ES and ED during successive R-R intervals in an interleaved manner. Each healthy volunteer (N = 3) received two injections of HP [1-¹³ C]pyruvate for the dual-phase imaging on the short-axis and the vertical long-axis planes. Spatial distribution of HP ¹³ C metabolites at each cardiac phase was correlate

SUBMITTER: Ma J 

PROVIDER: S-EPMC8616832 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature