Clinical translation of hyperpolarized ¹³ C pyruvate and urea MRI for simultaneous metabolic and perfusion imaging.

ABSTRACT:

Purpose

The combined hyperpolarized (HP) ¹³ C pyruvate and urea MRI has provided a simultaneous assessment of glycolytic metabolism and tissue perfusion for improved cancer diagnosis and therapeutic evaluation in preclinical studies. This work aims to translate this dual-probe HP imaging technique to clinical research.

Methods

A co-polarization system was developed where [1-¹³ C]pyruvic acid (PA) and [¹³ C, ¹⁵ N₂ ]urea in water solution were homogeneously mixed and polarized on a 5T SPINlab system. Physical and chemical characterizations and toxicology studies of the combined probe were performed. Simultaneous metabolic and perfusion imaging was performed on a 3T clinical MR scanner by alternatively applying a multi-slic

SUBMITTER: Qin H 

PROVIDER: S-EPMC8616838 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature