Oxytocin-pathway polygenic scores for severe mental disorders and metabolic phenotypes in the UK Biobank.

ABSTRACT: Oxytocin is a neuromodulator and hormone that is typically associated with social cognition and behavior. In light of its purported effects on social cognition and behavior, research has investigated its potential as a treatment for psychiatric illnesses characterized by social dysfunction, such as schizophrenia and bipolar disorder. While the results of these trials have been mixed, more recent evidence suggests that the oxytocin system is also linked with cardiometabolic conditions for which individuals with severe mental disorders are at a higher risk for developing. To investigate whether the oxytocin system has a pleiotropic effect on the etiology of severe mental illness and cardiometabolic conditions, we explored oxytocin's role in the shared genetic liability of schizophrenia, bipo

SUBMITTER: Winterton A 

PROVIDER: S-EPMC8616952 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature