Electrochemical C-H phosphorylation of arenes in continuous flow suitable for late-stage functionalization.

ABSTRACT: The development of efficient and sustainable methods for carbon-phosphorus bond formation is of great importance due to the wide application of organophosphorus compounds in chemistry, material sciences and biology. Previous C-H phosphorylation reactions under nonelectrochemical or electrochemical conditions require directing groups, transition metal catalysts, or chemical oxidants and suffer from limited scope. Herein we disclose a catalyst- and external oxidant-free, electrochemical C-H phosphorylation reaction of arenes in continuous flow for the synthesis of aryl phosphorus compounds. The C-P bond is formed through the reaction of arenes with anodically generated P-radical cations, a class of reactive intermediates remained unexplored for synthesis despite intensive studies of P-radica

SUBMITTER: Long H 

PROVIDER: S-EPMC8616953 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature