Give me a pain that I am used to: distinct habituation patterns to painful and non-painful stimulation.

ABSTRACT: Pain habituation is associated with a decrease of activation in brain areas related to pain perception. However, little is known about the specificity of these decreases to pain, as habituation has also been described for other responses like spinal reflexes and other sensory responses. Thus, it might be hypothesized that previously reported reductions in activation are not specifically related to pain habituation. For this reason, we performed a 3 T fMRI study using either painful or non-painful electrical stimulation via an electrode attached to the back of the left hand. Contrasting painful vs. non-painful stimulation revealed significant activation clusters in regions well-known to be related to pain processing, such as bilateral anterior and posterior insula, primary/secondary sensory

SUBMITTER: Paul K 

PROVIDER: S-EPMC8617189 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature