Author Correction: Genomic and transcriptomic correlates of immunotherapy response within the tumor microenvironment of leptomeningeal metastases.
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ABSTRACT:
SUBMITTER: Prakadan SM
PROVIDER: S-EPMC8617205 | biostudies-literature | 2021 Nov
REPOSITORIES: biostudies-literature
Publications
Author Correction: Genomic and transcriptomic correlates of immunotherapy response within the tumor microenvironment of leptomeningeal metastases.
Prakadan Sanjay M SM Alvarez-Breckenridge Christopher A CA Markson Samuel C SC Kim Albert E AE Klein Robert H RH Nayyar Naema N Navia Andrew W AW Kuter Benjamin M BM Kolb Kellie E KE Bihun Ivanna I Mora Joana L JL Bertalan Mia Solana MS Shaw Brian B White Michael M Kaplan Alexander A Stocking Jackson H JH Wadsworth Marc H MH Lee Eudocia Q EQ Chukwueke Ugonma U Wang Nancy N Subramanian Megha M Rotem Denisse D Cahill Daniel P DP Adalsteinsson Viktor A VA Miller Jeffrey W JW Sullivan Ryan J RJ Carter Scott L SL Brastianos Priscilla K PK Shalek Alex K AK
Nature communications 20211125 1
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Project description:An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Project description:We describe the clinical and therapeutic course of a 51-year-old woman with HER-2+ breast cancer who developed leptomeningeal (LM) and spinal cord metastases after 8 years of stable disease on combination therapy with intravenous (IV) trastuzumab. Due to progressive CNS disease, intrathecal (IT) trastuzumab was introduced to enhance HER-2+ therapy into the CSF space. A combination HER-2+ targeted approach achieved clinical remission with stable disease in our patient 46 months after she was diagnosed with LM metastases. However, spinal cord C-1 metastasis was not fully controlled with IT trastuzumab, ultimately leading to the patient's respiratory compromise. In our patient, IT trastuzumab immunotherapy improved prognosis and was an effective strategy to manage HER-2+ LM disease. Given alone or alongside other anti-HER-2+ therapeutics with sufficient CNS penetration, IT trastuzumab could extend the lifespan of patients with leptomeningeal and CNS metastases.
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