Pediatric COVID-19 patients in South Brazil show abundant viral mRNA and strong specific anti-viral responses.

ABSTRACT: COVID-19 manifests as a milder disease in children than adults, but the underlying mechanisms are not fully characterized. Here we assess the difference in cellular or humoral immune responses of pediatric and adult COVID-19 patients to see if these factors contribute to the severity dichotomy. Children's non-specific immune profile is dominated by naive lymphocytes and HLA-DR^highCX3CR1^low dendritic cells; meanwhile, children show strong specific antibody and T cell responses for viral structural proteins, with their T cell responses differing from adults by having weaker CD8⁺TNF⁺ T cells responses to S peptide pool but stronger responses to N and M peptide pools. Finally, viral mRNA is more abundant in pediatric patients. Our data thus support a

SUBMITTER: Fazolo T 

PROVIDER: S-EPMC8617275 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature